God Mode combines non-linear gameplay, fast and frantic shooting, hordes of on-screen enemies, and stunning visuals. The game hosts a single-player mode, as well as online and offline (via LAN) co-op play with 1-4 players. In addition to accessing more than 11 different weapons for battle, players are also equipped with a special ability fueled by Rage, which is gathered by amassing kills. Players can choose from several different powers ranging from offensive, to defensive, to support; all of which can be upgraded.

A series of in-game modifiers known as Tests of Faith alter gameplay on the fly and ensure that matches rarely--if ever--play out the same way twice. Each character is fully customizable, both in appearance and equipment, which evolve throughout the game. Gold and experience are accrued by players in a reward system to unlock new weapons and unique, powerful abilities, both of which have the option for further upgrades.